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Binding-induced functional-domain motions in the Argonaute characterized by adaptive advanced sampling

Argonaute proteins in combination with short microRNA (miRNAs) can target mRNA molecules for translation inhibition or degradation and play a key role in many regulatory processes. The miRNAs act as guide RNAs that associate with Argonaute and the complementary mRNA target region. The complex format...

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Detalles Bibliográficos
Autores principales: Pourjafar-Dehkordi, Danial, Zacharias, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683029/
https://www.ncbi.nlm.nih.gov/pubmed/34843451
http://dx.doi.org/10.1371/journal.pcbi.1009625