XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair

Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological disease triggered by toxic activity of the single-strand-break sensor protein PARP1. However, the mechanism(s) by which this toxic PARP1 activity triggers cellular dysfunction are unclear. Here we show that h...

Descripción completa

Detalles Bibliográficos
Autores principales: Adamowicz, Marek, Hailstone, Richard, Demin, Annie A., Komulainen, Emilia, Hanzlikova, Hana, Brazina, Jan, Gautam, Amit, Wells, Sophie E., Caldecott, Keith W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683375/
https://www.ncbi.nlm.nih.gov/pubmed/34811483
http://dx.doi.org/10.1038/s41556-021-00792-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683375/
https://www.ncbi.nlm.nih.gov/pubmed/34811483
http://dx.doi.org/10.1038/s41556-021-00792-w

Ejemplares similares