Cargando…

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair

Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological disease triggered by toxic activity of the single-strand-break sensor protein PARP1. However, the mechanism(s) by which this toxic PARP1 activity triggers cellular dysfunction are unclear. Here we show that h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adamowicz, Marek, Hailstone, Richard, Demin, Annie A., Komulainen, Emilia, Hanzlikova, Hana, Brazina, Jan, Gautam, Amit, Wells, Sophie E., Caldecott, Keith W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683375/ https://www.ncbi.nlm.nih.gov/pubmed/34811483 http://dx.doi.org/10.1038/s41556-021-00792-w

Ejemplares similares

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
por: Demin, Annie A., et al.
Publicado: (2021)

Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin
por: Hanzlikova, Hana, et al.
Publicado: (2017)

XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia
por: Hoch, Nicolas, et al.
Publicado: (2016)

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function
por: Breslin, Claire, et al.
Publicado: (2015)

PARP inhibition impedes the maturation of nascent DNA strands during DNA replication
por: Vaitsiankova, Alina, et al.
Publicado: (2022)

Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures
por: Komulainen, Emilia, et al.
Publicado: (2021)

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
por: Serrano‐Benitez, Almudena, et al.
Publicado: (2023)

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication
por: Hanzlikova, Hana, et al.
Publicado: (2018)

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
por: Hanzlikova, Hana, et al.
Publicado: (2020)

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ
por: Kalasova, Ilona, et al.
Publicado: (2019)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair
por: Campalans, Anna, et al.
Publicado: (2013)

Multifunctional adaptor protein Daxx interacts with chromatin-remodelling ATPase Brg1
por: Svadlenka, Jan, et al.
Publicado: (2015)

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
por: Polo, Luis M., et al.
Publicado: (2019)

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains
por: Cherry, Amy L., et al.
Publicado: (2015)

PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response
por: Reber, Julia M., et al.
Publicado: (2022)

Genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1
por: Lee, Youngsoo, et al.
Publicado: (2009)

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase
por: Brazina, Jan, et al.
Publicado: (2015)

PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner
por: Veith, Sebastian, et al.
Publicado: (2019)

Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia
por: Mahjoub, Areej, et al.
Publicado: (2019)

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining
por: Soni, Aashish, et al.
Publicado: (2014)

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair
por: Breslin, Claire, et al.
Publicado: (2017)

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk
por: Kaur, Jagjeet, et al.
Publicado: (2020)

BRAT1 links Integrator and defective RNA processing with neurodegeneration
por: Cihlarova, Zuzana, et al.
Publicado: (2022)

HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation
por: Kumamoto, Soichiro, et al.
Publicado: (2021)

ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition
por: Giovannini, Sara, et al.
Publicado: (2020)

MicroRNA-379-5p is associated with biochemical premature ovarian insufficiency through PARP1 and XRCC6
por: Dang, Yujie, et al.
Publicado: (2018)

A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer
por: Mandegari, Mohammad, et al.
Publicado: (2021)

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
por: Kutuzov, M. M., et al.
Publicado: (2021)

XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA
por: Hirota, Kouji, et al.
Publicado: (2022)

PARP inhibitor olaparib enhances the efficacy of radiotherapy on XRCC2-deficient colorectal cancer cells
por: Qin, Changjiang, et al.
Publicado: (2022)

Berberine attenuates XRCC1‐mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs
por: Gao, Xingjie, et al.
Publicado: (2019)

Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer
por: Santos, Juliana C., et al.
Publicado: (2014)

Polymorphism of XRCC1, XRCC3, and XPD Genes and Risk of Chronic Myeloid Leukemia
por: Bănescu, Claudia, et al.
Publicado: (2014)

Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck
por: Kowalski, Michal, et al.
Publicado: (2009)

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
por: Ronson, George E., et al.
Publicado: (2018)

PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes
por: Zakharenko, A. L., et al.
Publicado: (2023)

Predictive value of single nucleotide polymorphisms in XRCC1 for radiation-induced normal tissue toxicity
por: Zhao, Jing, et al.
Publicado: (2018)

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
por: Pines, Alex, et al.
Publicado: (2012)

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage
por: Rulten, Stuart L., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_diajgebii3gpbem10bt09sfteo