Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

Chronic mental illnesses (CMIs) pose a significant challenge to global health due to their complex and poorly understood etiologies and hence, absence of causal therapies. Research of the past two decades has revealed dysfunction of the disrupted in schizophrenia 1 (DISC1) protein as a predisposing...

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Detalles Bibliográficos
Autores principales: Cukkemane, Abhishek, Becker, Nina, Zielinski, Mara, Frieg, Benedikt, Lakomek, Nils-Alexander, Heise, Henrike, Schröder, Gunnar F., Willbold, Dieter, Weiergräber, Oliver H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683410/
https://www.ncbi.nlm.nih.gov/pubmed/34921141
http://dx.doi.org/10.1038/s41398-021-01765-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683410/
https://www.ncbi.nlm.nih.gov/pubmed/34921141
http://dx.doi.org/10.1038/s41398-021-01765-1

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