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Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses
Chronic mental illnesses (CMIs) pose a significant challenge to global health due to their complex and poorly understood etiologies and hence, absence of causal therapies. Research of the past two decades has revealed dysfunction of the disrupted in schizophrenia 1 (DISC1) protein as a predisposing...
Autores principales: | Cukkemane, Abhishek, Becker, Nina, Zielinski, Mara, Frieg, Benedikt, Lakomek, Nils-Alexander, Heise, Henrike, Schröder, Gunnar F., Willbold, Dieter, Weiergräber, Oliver H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683410/ https://www.ncbi.nlm.nih.gov/pubmed/34921141 http://dx.doi.org/10.1038/s41398-021-01765-1 |
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