Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex microenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however the effects of individual stromal subsets remain incompletely characterised. Here, we describe...

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Detalles Bibliográficos
Autores principales: Lee, Brian Y., Hogg, Elizabeth K. J., Below, Christopher R., Kononov, Alexander, Blanco-Gomez, Adrian, Heider, Felix, Xu, Jingshu, Hutton, Colin, Zhang, Xiaohong, Scheidt, Tamara, Beattie, Kenneth, Lamarca, Angela, McNamara, Mairéad, Valle, Juan W., Jørgensen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683436/
https://www.ncbi.nlm.nih.gov/pubmed/34921158
http://dx.doi.org/10.1038/s41467-021-27607-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683436/
https://www.ncbi.nlm.nih.gov/pubmed/34921158
http://dx.doi.org/10.1038/s41467-021-27607-8

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