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Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex microenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however the effects of individual stromal subsets remain incompletely characterised. Here, we describe...
Autores principales: | Lee, Brian Y., Hogg, Elizabeth K. J., Below, Christopher R., Kononov, Alexander, Blanco-Gomez, Adrian, Heider, Felix, Xu, Jingshu, Hutton, Colin, Zhang, Xiaohong, Scheidt, Tamara, Beattie, Kenneth, Lamarca, Angela, McNamara, Mairéad, Valle, Juan W., Jørgensen, Claus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683436/ https://www.ncbi.nlm.nih.gov/pubmed/34921158 http://dx.doi.org/10.1038/s41467-021-27607-8 |
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