Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms

The mouse Igf2/H19 locus is regulated by genomic imprinting, in which the paternally methylated H19 imprinting control region (ICR) plays a critical role in mono-allelic expression of the genes in the locus. Although the maternal allele-specific insulator activity of the H19 ICR in regulating imprin...

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Detalles Bibliográficos
Autores principales: Matsuzaki, Hitomi, Miyajima, Yu, Fukamizu, Akiyoshi, Tanimoto, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683476/
https://www.ncbi.nlm.nih.gov/pubmed/34921234
http://dx.doi.org/10.1038/s42003-021-02939-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683476/
https://www.ncbi.nlm.nih.gov/pubmed/34921234
http://dx.doi.org/10.1038/s42003-021-02939-9

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