RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding

NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles and oxidation, promotes NRF2 degradation in unstressed conditions. SQSTM1/p62, an oncogenic protein aberrantly accumulated in hepatocellular carcinoma (...

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Detalles Bibliográficos
Autores principales: Feng, Xiaofan, Jiang, Tianyi, Yang, Chun, Pang, Shujie, Ding, Zhiwen, Hu, Heping, Wang, Hui, Dong, Liwei, Yang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683478/
https://www.ncbi.nlm.nih.gov/pubmed/34921137
http://dx.doi.org/10.1038/s41419-021-04447-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683478/
https://www.ncbi.nlm.nih.gov/pubmed/34921137
http://dx.doi.org/10.1038/s41419-021-04447-4

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