Restoring Shank3 in the rostral brainstem of shank3ab−/− zebrafish autism models rescues sensory deficits

People with Phelan-McDermid Syndrome, caused by mutations in the SHANK3 gene, commonly exhibit reduced responses to sensory stimuli; yet the changes in brain-wide activity that link these symptoms to mutations in the shank3 gene remain unknown. Here we quantify movement in response to sudden darknes...

Descripción completa

Detalles Bibliográficos
Autores principales: Kozol, Robert A., James, David M., Varela, Ivan, Sumathipala, Sureni H., Züchner, Stephan, Dallman, Julia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683502/
https://www.ncbi.nlm.nih.gov/pubmed/34921227
http://dx.doi.org/10.1038/s42003-021-02920-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683502/
https://www.ncbi.nlm.nih.gov/pubmed/34921227
http://dx.doi.org/10.1038/s42003-021-02920-6

Ejemplares similares