SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease

BACKGROUND: Senataxin (SETX) is a DNA/RNA helicase critical for neuron survival. SETX mutations underlie two inherited neurodegenerative diseases: Ataxia with Oculomotor Apraxia type 2 (AOA2) and Amyotrophic Lateral Sclerosis type 4 (ALS4). METHODS: This review examines SETX key cellular processes a...

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Detalles Bibliográficos
Autores principales: Bennett, Craig L., La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683630/
https://www.ncbi.nlm.nih.gov/pubmed/34263556
http://dx.doi.org/10.1002/mgg3.1745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683630/
https://www.ncbi.nlm.nih.gov/pubmed/34263556
http://dx.doi.org/10.1002/mgg3.1745

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