Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs

Designed ankyrin repeat proteins (DARPins) are antibody mimetics with high and mostly unexplored potential in drug development. By using in silico analysis and a rationally guided Ala scanning, we identified position 17 of the N-terminal capping repeat to play a key role in overall protein thermosta...

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Detalles Bibliográficos
Autores principales: Schilling, Johannes, Jost, Christian, Ilie, Ioana Mariuca, Schnabl, Joachim, Buechi, Oralea, Eapen, Rohan S., Truffer, Rafaela, Caflisch, Amedeo, Forrer, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683736/
https://www.ncbi.nlm.nih.gov/pubmed/34793836
http://dx.doi.org/10.1016/j.jbc.2021.101403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683736/
https://www.ncbi.nlm.nih.gov/pubmed/34793836
http://dx.doi.org/10.1016/j.jbc.2021.101403

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