PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

BACKGROUND: Protein disulfide isomerase A3 (PDIA3, also named GRP58, ER-60, ERp57) is conserved across species and mediates protein folding in the endoplasmic reticulum. PDIA3 is, reportedly, a chaperone for STAT3. However, the role of PDIA3 in regulating mitochondrial bioenergetics and STAT3 phosph...

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Detalles Bibliográficos
Autores principales: Keasey, Matt. P., Razskazovskiy, V., Jia, C., Peterknecht, E. D., Bradshaw, P. C., Hagg, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684072/
https://www.ncbi.nlm.nih.gov/pubmed/34922569
http://dx.doi.org/10.1186/s12964-021-00794-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684072/
https://www.ncbi.nlm.nih.gov/pubmed/34922569
http://dx.doi.org/10.1186/s12964-021-00794-z

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