Oxygen nanocarrier broke the hypoxia trap of solid tumors and rescued transfection efficiency for gene therapy

BACKGROUND: Gene therapy shows great promise for a broad array of diseases. However, we found that hypoxic tumor microenvironment (TME) exerted significant inhibitory effects on transfection efficiency of a variety of gene vectors (such as Lipo 2000 and PEI) in an oxygen-dependent manner. Solid tumo...

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Detalles Bibliográficos
Autores principales: Qin, Bing, Jiang, Mengshi, Li, Xiang, Shi, Yingying, Zhang, Junlei, Luo, Zhenyu, Luo, Lihua, Lu, Yichao, Liu, Xu, Wang, Sijie, Du, Yongzhong, Qiu, Yunqing, Lou, Yan, You, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684184/
https://www.ncbi.nlm.nih.gov/pubmed/34922537
http://dx.doi.org/10.1186/s12951-021-01144-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684184/
https://www.ncbi.nlm.nih.gov/pubmed/34922537
http://dx.doi.org/10.1186/s12951-021-01144-4

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