PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation

BACKGROUND: Phosphoinositide-3-kinase-delta (PI3Kδ) inhibition is a promising therapeutic approach for inflammatory conditions due to its role in leucocyte proliferation, migration and activation. However, the effect of PI3Kδ inhibition on group 2 innate lymphoid cells (ILC2s) and inflammatory eosin...

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Detalles Bibliográficos
Autores principales: Uddin, Sorif, Amour, Augustin, Lewis, David J., Edwards, Chris D., Williamson, Matthew G., Hall, Simon, Lione, Lisa A., Hessel, Edith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684271/
https://www.ncbi.nlm.nih.gov/pubmed/34920698
http://dx.doi.org/10.1186/s12865-021-00461-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684271/
https://www.ncbi.nlm.nih.gov/pubmed/34920698
http://dx.doi.org/10.1186/s12865-021-00461-5

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