CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits

BACKGROUND: High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. We aim to create APOC3-knockout (KO) rabbits and explore the effects of APOC3 deletion on the occurrence and development of atherosclerosis. METHODS: An sgRNA an...

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Detalles Bibliográficos
Autores principales: Zha, Yiwen, Lu, Yaoyao, Zhang, Ting, Yan, Kunning, Zhuang, Wenwen, Liang, Jingyan, Cheng, Yong, Wang, Yingge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684289/
https://www.ncbi.nlm.nih.gov/pubmed/34922545
http://dx.doi.org/10.1186/s12944-021-01605-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684289/
https://www.ncbi.nlm.nih.gov/pubmed/34922545
http://dx.doi.org/10.1186/s12944-021-01605-7

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