Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury

PURPOSE: Optic nerve injury (ONI) causes neuroinflammation and neurodegeneration leading to visual deficits. The response of microglia has emerged as an impactful component of etiology in neurodegeneration. This study aimed to investigate the effect of SIRT1-mTORC1 signaling pathway in microglia reg...

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Detalles Bibliográficos
Autores principales: Mou, Qianxue, Yao, Ke, Ye, Meng, Zhao, Bowen, Hu, Yuanyuan, Lou, Xiaotong, Li, Huixia, Zhang, Hong, Zhao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684404/
https://www.ncbi.nlm.nih.gov/pubmed/34934336
http://dx.doi.org/10.2147/JIR.S338815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684404/
https://www.ncbi.nlm.nih.gov/pubmed/34934336
http://dx.doi.org/10.2147/JIR.S338815

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