Key role of a structural water molecule for the specificity of 14F7—An antitumor antibody targeting the NeuGc GM3 ganglioside

Tumor-associated glycolipids such as NeuGc GM3 are auspicious molecular targets in antineoplastic therapies and vaccine strategies. 14F7 is a monoclonal IgG1 with high clinical potential in cancer immunotherapy as it displays extraordinary specificity for NeuGc GM3, while it does not recognize the v...

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Detalles Bibliográficos
Autores principales: Bjerregaard-Andersen, Kaare, Abraha, Fana, Johannesen, Hedda, Oscarson, Stefan, Moreno, Ernesto, Krengel, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Glycan Recognition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684480/
https://www.ncbi.nlm.nih.gov/pubmed/34735569
http://dx.doi.org/10.1093/glycob/cwab076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684480/
https://www.ncbi.nlm.nih.gov/pubmed/34735569
http://dx.doi.org/10.1093/glycob/cwab076

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