Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo

BACKGROUND: Osteosarcoma is the third most common cancer in adolescence and the first common primary malignant tumor of bone. The long-term prognosis of osteosarcoma still remains unsatisfactory in the past decades. Therefore, development of novel therapeutic agents which are effective to osteosarco...

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Detalles Bibliográficos
Autores principales: Lv, Minchao, Xu, Qingxin, Zhang, Bei, Yang, Zhiqiang, Xie, Jun, Guo, Jinku, He, Feixiong, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684670/
https://www.ncbi.nlm.nih.gov/pubmed/34923996
http://dx.doi.org/10.1186/s12935-021-02397-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684670/
https://www.ncbi.nlm.nih.gov/pubmed/34923996
http://dx.doi.org/10.1186/s12935-021-02397-7

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