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p52Shc regulates the sustainability of ERK activation in a RAF-independent manner

p52SHC (SHC) and GRB2 are adaptor proteins involved in the RAS/MAPK (ERK) pathway mediating signals from cell-surface receptors to various cytoplasmic proteins. To further examine their roles in signal transduction, we studied the translocation of fluorescently labeled SHC and GRB2 to the cell surfa...

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Detalles Bibliográficos
Autores principales: Yoshizawa, Ryo, Umeki, Nobuhisa, Yamamoto, Akihiro, Okada, Mariko, Murata, Masayuki, Sako, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684710/
https://www.ncbi.nlm.nih.gov/pubmed/34260260
http://dx.doi.org/10.1091/mbc.E21-01-0007