Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome

Mutations in the hedgehog (Hh) signaling are implicated in birth defects and cancers, including medulloblastoma (MB), one of the most malignant pediatric brain tumors. Current Hh inhibitors face the challenge of drug resistance and tumor relapse, urging new insights in the Hh pathway regulation. Our...

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Detalles Bibliográficos
Autores principales: Peng, Hualing, Zhang, Jingyi, Ya, Amanda, Ma, Winston, Villa, Sammy, Sukenik, Shahar, Ge, Xuecai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684712/
https://www.ncbi.nlm.nih.gov/pubmed/34260267
http://dx.doi.org/10.1091/mbc.E21-02-0064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684712/
https://www.ncbi.nlm.nih.gov/pubmed/34260267
http://dx.doi.org/10.1091/mbc.E21-02-0064

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