E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6

Multiciliated cells play critical roles in the airway, reproductive organs, and brain. Generation of multiple cilia requires both activation of a specialized transcriptional program and subsequent massive amplification of centrioles within the cytoplasm. The E2F4 transcription factor is required for...

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Detalles Bibliográficos
Autores principales: Hazan, Renin, Mori, Munemasa, Danielian, Paul S., Guen, Vincent J., Rubin, Seth M., Cardoso, Wellington V., Lees, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684742/
https://www.ncbi.nlm.nih.gov/pubmed/34260288
http://dx.doi.org/10.1091/mbc.E21-01-0039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684742/
https://www.ncbi.nlm.nih.gov/pubmed/34260288
http://dx.doi.org/10.1091/mbc.E21-01-0039

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