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Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

In Dictyostelium, chemoattractants induce a fast cGMP response that mediates myosin filament formation in the rear of the cell. The major cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated cGMP-specific phosphodiesterase, and the cGMP-target protein GbpC. Here we co...

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Detalles Bibliográficos
Autores principales: van Haastert, Peter J. M., Keizer-Gunnink, Ineke, Pots, Henderikus, Ortiz-Mateos, Claudia, Veltman, Douwe, van Egmond, Wouter, Kortholt, Arjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684759/
https://www.ncbi.nlm.nih.gov/pubmed/34347507
http://dx.doi.org/10.1091/mbc.E21-04-0171