A two-phase bromination process using tetraalkylammonium hydroxide for the practical synthesis of α-bromolactones from lactones

A simple and efficient method for α-brominating lactones that affords α-bromolactones under mild conditions using tetraalkylammonium hydroxide (R(4)N(+)OH(−)) as a base was developed. Lactones are ring-opened with Br(2) and a substoichiometric amount of PBr(3), leading to good yields of the correspo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamamoto, Yuki, Tabuchi, Akihiro, Hosono, Kazumi, Ochi, Takanori, Yamazaki, Kento, Kodama, Shintaro, Nomoto, Akihiro, Ogawa, Akiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685563/
https://www.ncbi.nlm.nih.gov/pubmed/34956409
http://dx.doi.org/10.3762/bjoc.17.198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685563/
https://www.ncbi.nlm.nih.gov/pubmed/34956409
http://dx.doi.org/10.3762/bjoc.17.198

Ejemplares similares