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A two-phase bromination process using tetraalkylammonium hydroxide for the practical synthesis of α-bromolactones from lactones

A simple and efficient method for α-brominating lactones that affords α-bromolactones under mild conditions using tetraalkylammonium hydroxide (R(4)N(+)OH(−)) as a base was developed. Lactones are ring-opened with Br(2) and a substoichiometric amount of PBr(3), leading to good yields of the correspo...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yuki, Tabuchi, Akihiro, Hosono, Kazumi, Ochi, Takanori, Yamazaki, Kento, Kodama, Shintaro, Nomoto, Akihiro, Ogawa, Akiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685563/
https://www.ncbi.nlm.nih.gov/pubmed/34956409
http://dx.doi.org/10.3762/bjoc.17.198
Descripción
Sumario:A simple and efficient method for α-brominating lactones that affords α-bromolactones under mild conditions using tetraalkylammonium hydroxide (R(4)N(+)OH(−)) as a base was developed. Lactones are ring-opened with Br(2) and a substoichiometric amount of PBr(3), leading to good yields of the corresponding α-bromocarboxylic acids. Subsequent intramolecular cyclization over 1 h using a two-phase system (H(2)O/CHCl(3)) containing R(4)N(+)OH(−) afforded α-bromo lactones in good yields. This method can be applied at the 10 mmol scale using simple operations. α-Bromo-δ-valerolactone, which is extremely reactive and difficult to isolate, could be isolated and stored in a freezer for about one week using the developed method. Optimizing the solvent for environmentally friendly large-scale syntheses revealed that methyl ethyl ketone (MEK) was as effective. In addition, in situ-generated α-bromo-δ-valerolactone was directly converted into a sulfur-substituted functional lactone without difficulty by reacting it with a sulfur nucleophile in one pot without isolation. This new bromination system is expected to facilitate the industrial use of α-bromolactones as important intermediates.