A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created an urgent need for new technologies to treat COVID-19. Here we report a 2′-fluoro protected RNA aptamer that binds with high affinity to the receptor binding domain (RBD) of SARS-CoV-2 spike protein, thereby preven...

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Detalles Bibliográficos
Autores principales: Valero, Julián, Civit, Laia, Dupont, Daniel M., Selnihhin, Denis, Reinert, Line S., Idorn, Manja, Israels, Brett A., Bednarz, Aleksandra M., Bus, Claus, Asbach, Benedikt, Peterhoff, David, Pedersen, Finn S., Birkedal, Victoria, Wagner, Ralf, Paludan, Søren R., Kjems, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685691/
https://www.ncbi.nlm.nih.gov/pubmed/34876524
http://dx.doi.org/10.1073/pnas.2112942118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685691/
https://www.ncbi.nlm.nih.gov/pubmed/34876524
http://dx.doi.org/10.1073/pnas.2112942118

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