One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma

EWS/FLI is the defining mutation of Ewing sarcoma. This oncogene drives malignant transformation and progression and occurs in a genetic background characterized by few other recurrent cooperating mutations. In addition, the tumor is absolutely dependent on the continued expression of EWS/FLI to mai...

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Detalles Bibliográficos
Autores principales: Flores, Guillermo, Grohar, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
VSI: Bone Sarcoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686064/
https://www.ncbi.nlm.nih.gov/pubmed/34976713
http://dx.doi.org/10.1016/j.jbo.2021.100404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686064/
https://www.ncbi.nlm.nih.gov/pubmed/34976713
http://dx.doi.org/10.1016/j.jbo.2021.100404

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