Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation

Rif1 regulates DNA replication timing and double-strand break repair, and its depletion induces transcriptional bursting of two-cell (2C) zygote-specific genes in mouse ES cells. However, how Rif1 regulates zygotic transcription is unclear. We show here that Rif1 depletion promotes the formation of...

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Detalles Bibliográficos
Autores principales: Yoshizawa-Sugata, Naoko, Yamazaki, Satoshi, Mita-Yoshida, Kaoru, Ono, Tomio, Nishito, Yasumasa, Masai, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686075/
https://www.ncbi.nlm.nih.gov/pubmed/34736895
http://dx.doi.org/10.1016/j.jbc.2021.101367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686075/
https://www.ncbi.nlm.nih.gov/pubmed/34736895
http://dx.doi.org/10.1016/j.jbc.2021.101367

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