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Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review

BACKGROUND: The development of novel malaria vaccines and antimalarial drugs is limited partly by emerging challenges to conduct field trials in malaria endemic areas, including unknown effects of existing immunity and a reported fall in malaria incidence. As a result, Controlled Human Malaria Infec...

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Detalles Bibliográficos
Autores principales: Shibeshi, Workineh, Bagchus, Wilhelmina, Yalkinoglu, Özkan, Tappert, Aliona, Engidawork, Ephrem, Oeuvray, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686662/
https://www.ncbi.nlm.nih.gov/pubmed/34930178
http://dx.doi.org/10.1186/s12879-021-06953-4