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A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches

Antibody-based drugs can be highly toxic, because they target normal tissue as well as tumor tissue. The pH value of the extracellular microenvironments around tumor tissues is lower than that of normal tissues. Therefore, antibodies that engage in pH-dependent binding at slightly acidic pH are cruc...

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Detalles Bibliográficos
Autores principales: Zou, Wenjun, Huang, Chuncui, Sun, Qing, Zhao, Keli, Gao, Huanyu, Su, Rong, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686790/
https://www.ncbi.nlm.nih.gov/pubmed/34956814
http://dx.doi.org/10.1007/s13205-021-03079-x