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A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches
Antibody-based drugs can be highly toxic, because they target normal tissue as well as tumor tissue. The pH value of the extracellular microenvironments around tumor tissues is lower than that of normal tissues. Therefore, antibodies that engage in pH-dependent binding at slightly acidic pH are cruc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686790/ https://www.ncbi.nlm.nih.gov/pubmed/34956814 http://dx.doi.org/10.1007/s13205-021-03079-x |