Cargando…

GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis

Viruses have evolved multiple strategies to manipulate their host’s translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α). In this study, we show that global protein synthesis was increased but the eIF2α phos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Ting, Jiang, Xueli, Xin, Hangkuo, Zheng, Xiaohui, Xue, Xiaonuan, Chen, Ji-Long, Qi, Baomin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686791/ https://www.ncbi.nlm.nih.gov/pubmed/34930429 http://dx.doi.org/10.1186/s13567-021-01018-5

Ejemplares similares

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
por: Novoa, Isabel, et al.
Publicado: (2001)

GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor
por: Shi, Weibin, et al.
Publicado: (2004)

Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells
por: Teng, Y, et al.
Publicado: (2014)

GADD34 is a modulator of autophagy during starvation
por: Gambardella, Gennaro, et al.
Publicado: (2020)

Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis
por: Sequeira, Sharon J, et al.
Publicado: (2009)

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage
por: Matsuoka, Masato, et al.
Publicado: (2015)

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
por: Crespillo-Casado, Ana, et al.
Publicado: (2017)

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α
por: Lee, Duckgue, et al.
Publicado: (2019)

Meclizine Inhibits Pseudorabies Virus Replication by Interfering With Virus Entry and Release
por: Liu, Panrao, et al.
Publicado: (2021)

Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury
por: Tang, Yong-Jing, et al.
Publicado: (2020)

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant
por: Eytan, Karin, et al.
Publicado: (2022)

Arrestin Facilitates Rhodopsin Dephosphorylation in Vivo
por: Hsieh, Chia-Ling, et al.
Publicado: (2022)

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing
por: Liu, Lintao, et al.
Publicado: (2014)

RhoA suppresses pseudorabies virus replication in vitro
por: Li, Xin-Man, et al.
Publicado: (2023)

Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication
por: Alfred, Niyokwishimira, et al.
Publicado: (2021)

EBNA3C interacts with Gadd34 and counteracts the unfolded protein response
por: Garrido, Jose L, et al.
Publicado: (2009)

GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy
por: Ito, Sachiko, et al.
Publicado: (2015)

Inhibition of EIF2α Dephosphorylation Decreases Cell Viability and Synergizes with Standard-of-Care Chemotherapeutics in Head and Neck Squamous Cell Carcinoma
por: Cyran, Anna M., et al.
Publicado: (2023)

Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34
por: Sun, Yang, et al.
Publicado: (2015)

GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice
por: Saltykova, Irina V., et al.
Publicado: (2022)

GADD34 activates p53 and may have utility as a marker of atherosclerosis
por: Tomiyoshi, Go, et al.
Publicado: (2023)

Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice
por: Tanaka, Yuriko, et al.
Publicado: (2015)

Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation
por: Gao, Ming, et al.
Publicado: (2013)

Host antiviral protein IFITM2 restricts pseudorabies virus replication
por: Xie, Jingying, et al.
Publicado: (2020)

Resveratrol Inhibits Pseudorabies Virus Replication by Targeting IE180 Protein
por: Chen, Xiangxiu, et al.
Publicado: (2022)

Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner
por: Yu, Chen-Lin, et al.
Publicado: (2019)

Gadd45β and Gadd45γ are critical for regulating autoimmunity
por: Liu, Lin, et al.
Publicado: (2005)

HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD34
por: Mukai, Risa, et al.
Publicado: (2011)

GADD34 induces cell death through inactivation of Akt following traumatic brain injury
por: Farook, J M, et al.
Publicado: (2013)

GADD34 induces cell death through inactivation of Akt following traumatic brain injury
por: Farook, J M, et al.
Publicado: (2013)

GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation
por: Ito, S, et al.
Publicado: (2016)

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy
por: Holczer, Marianna, et al.
Publicado: (2016)

Molecular docking studies of salubrinal and its analogs as inhibitors of the GADD34:PP1 enzyme
por: Zadorozhnii, Pavlo V., et al.
Publicado: (2019)

Geoffrey Michael Gadd
por: Gadd, Geoffrey Michael
Publicado: (2020)

Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses
por: Li, Xun, et al.
Publicado: (2019)

The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro
por: Zhang, Angke, et al.
Publicado: (2020)

Long non-coding RNA LNC_000641 regulates pseudorabies virus replication
por: Fang, Linlin, et al.
Publicado: (2021)

Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication
por: Yu, Pei-Lun, et al.
Publicado: (2023)

Directed stepwise tracing of polysynaptic neuronal circuits with replication-deficient pseudorabies virus
por: Du, Wenqin, et al.
Publicado: (2023)

Recombinant Porcine Interferon-α Decreases Pseudorabies Virus Infection
por: Song, Bowen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_skqkfldufob9ajqui5qgm9agsv