Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits

Secreted amyloid-β (Aβ) peptide forms neurotoxic oligomeric assemblies thought to cause synaptic deficits associated with Alzheimer’s disease (AD). Soluble Aβ oligomers (Aβo) directly bind to neurons with high affinity and block plasticity mechanisms related to learning and memory, trigger loss of e...

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Detalles Bibliográficos
Autores principales: Actor-Engel, Hannah S., Schwartz, Samantha L., Crosby, Kevin C., Sinnen, Brooke L., Prikhodko, Olga, Ramsay, Harrison J., Bourne, Jennifer N., Winborn, Christina S., Lucas, Alexandra, Smith, Katharine R., Dell’Acqua, Mark L., Kennedy, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687484/
https://www.ncbi.nlm.nih.gov/pubmed/34789478
http://dx.doi.org/10.1523/ENEURO.0416-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687484/
https://www.ncbi.nlm.nih.gov/pubmed/34789478
http://dx.doi.org/10.1523/ENEURO.0416-21.2021

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