Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways

A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IFN-γ), tum...

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Detalles Bibliográficos
Autores principales: Kurizky, Patrícia Shu, da Motta, Jorgeth de Oliveira Carneiro, Bezerra, Natanael Victor Furtunato, Sousa, Marcia Carolline dos Santos, Corazza, Danilo, Borges, Taiana Karla dos Santos, Gomes, Ciro Martins
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687500/
https://www.ncbi.nlm.nih.gov/pubmed/34932761
http://dx.doi.org/10.1590/0037-8682-0336-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687500/
https://www.ncbi.nlm.nih.gov/pubmed/34932761
http://dx.doi.org/10.1590/0037-8682-0336-2021

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