Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells

Ac3IV (Ac-CYIQNCPRG-NH(2)) is an enzymatically stable vasopressin analogue that selectively activates Avpr1a (V1a) and Avpr1b (V1b) receptors. In the current study we have employed streptozotocin (STZ) diabetic transgenic Ins1(Cre/+);Rosa26-eYFP and Glu(CreERT2);Rosa26-eYFP mice, to evaluate the imp...

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Detalles Bibliográficos
Autores principales: Mohan, Shruti, Lafferty, Ryan, Tanday, Neil, Flatt, Peter R., Moffett, R. Charlotte, Irwin, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687525/
https://www.ncbi.nlm.nih.gov/pubmed/34929019
http://dx.doi.org/10.1371/journal.pone.0261608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687525/
https://www.ncbi.nlm.nih.gov/pubmed/34929019
http://dx.doi.org/10.1371/journal.pone.0261608

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