SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut

BACKGROUND & AIMS: Single immunoglobulin interleukin-1–related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing enterocolitis (NEC). Herein, we investigated the mec...

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Detalles Bibliográficos
Autores principales: Yu, Wei, Haque, Inamul, Venkatraman, Aparna, Menden, Heather L., Mabry, Sherry M., Roy, Badal C., Xia, Sheng, Prokop, Jeremy W., Umar, Shahid, Geurts, Aron M., Sampath, Venkatesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688179/
https://www.ncbi.nlm.nih.gov/pubmed/34563711
http://dx.doi.org/10.1016/j.jcmgh.2021.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688179/
https://www.ncbi.nlm.nih.gov/pubmed/34563711
http://dx.doi.org/10.1016/j.jcmgh.2021.09.009

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