Loss of the Wild-type KRAS Allele Promotes Pancreatic Cancer Progression through Functional Activation of YAP1

Human pancreatic ductal adenocarcinoma (PDAC) harboring one KRAS mutant allele often displays increasing genomic loss of the remaining wild-type (WT) allele (known as LOH at KRAS) as tumors progress to metastasis, yet the molecular ramification of this WT allelic loss is unknown. In this study, we s...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Han, Yu, Chih-Chieh, Fine, Stuart A., Youssof, Ayman Lee, Yang, Ye-Ran, Yan, Jun, Karg, Dillon C., Cheung, Edwin C., Friedman, Richard A., Ying, Haoqiang, Chen, Emily I., Luo, Ji, Miao, Yi, Qiu, Wanglong, Su, Gloria H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688281/
https://www.ncbi.nlm.nih.gov/pubmed/34663879
http://dx.doi.org/10.1038/s41388-021-02040-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688281/
https://www.ncbi.nlm.nih.gov/pubmed/34663879
http://dx.doi.org/10.1038/s41388-021-02040-9

Ejemplares similares