Evaluating pediatric and adult simulated fluids solubility: Abraham solvation parameters and multivariate analysis

PURPOSE: To understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in pediatric patients. To assess the discrimination ability of the Abraham solvation parameters and age-related changes in simulated media composition to predict in vitro drug solubi...

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Detalles Bibliográficos
Autores principales: Guimarães, Mariana, Kuentz, Martin, Vertzoni, Maria, Fotaki, Nikoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688383/
https://www.ncbi.nlm.nih.gov/pubmed/34697725
http://dx.doi.org/10.1007/s11095-021-03123-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688383/
https://www.ncbi.nlm.nih.gov/pubmed/34697725
http://dx.doi.org/10.1007/s11095-021-03123-8

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