Scaling Down Large-Scale Thawing of Monoclonal Antibody Solutions: 3D Temperature Profiles, Changes in Concentration, and Density Gradients

PURPOSE: Scale-down devices (SDD) are designed to simulate large-scale thawing of protein drug substance, but require only a fraction of the material. To evaluate the performance of a new SDD that aims to predict thawing in large-scale 2 L bottles, we characterised 3D temperature profiles and change...

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Detalles Bibliográficos
Autores principales: Bluemel, Oliver, Buecheler, Jakob W., Hauptmann, Astrid, Hoelzl, Georg, Bechtold-Peters, Karoline, Friess, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688388/
https://www.ncbi.nlm.nih.gov/pubmed/34729702
http://dx.doi.org/10.1007/s11095-021-03117-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688388/
https://www.ncbi.nlm.nih.gov/pubmed/34729702
http://dx.doi.org/10.1007/s11095-021-03117-6

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