Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations

PURPOSE: Polysorbate excipients are commonly used as surfactants to stabilize therapeutic proteins in formulations. Degradation of polysorbates could lead to particle formation and instability of the drug formulation. We investigated how the fatty acid composition of polysorbate 80 impacts the degra...

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Detalles Bibliográficos
Autores principales: Pegues, Melissa A., Szczepanek, Karol, Sheikh, Faruk, Thacker, Seth G., Aryal, Baikuntha, Ghorab, Mohamed K, Wolfgang, Steven, Donnelly, Raymond P., Verthelyi, Daniela, Rao, V. Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688393/
https://www.ncbi.nlm.nih.gov/pubmed/34845573
http://dx.doi.org/10.1007/s11095-021-03125-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688393/
https://www.ncbi.nlm.nih.gov/pubmed/34845573
http://dx.doi.org/10.1007/s11095-021-03125-6

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