The activation fragment of PAR2 is elevated in serum from patients with rheumatoid arthritis and reduced in response to anti-IL6R treatment

Osteoarthritis (OA) and rheumatoid arthritis (RA) are serious and painful diseases. Protease-activated receptor 2 (PAR2) is involved in the pathology of both OA and RA including roles in synovial hyperplasia, cartilage destruction, osteophyogenesis and pain. PAR2 is activated via cleavage of its N-t...

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Detalles Bibliográficos
Autores principales: Kalogera, Stefania, He, Yi, Bay-Jensen, Anne-Christine, Gantzel, Thorbjørn, Sun, Shu, Manon-Jensen, Tina, Karsdal, Morten Asser, Thudium, Christian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688421/
https://www.ncbi.nlm.nih.gov/pubmed/34930943
http://dx.doi.org/10.1038/s41598-021-03346-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688421/
https://www.ncbi.nlm.nih.gov/pubmed/34930943
http://dx.doi.org/10.1038/s41598-021-03346-0

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