CDK5RAP2 loss-of-function causes premature cell senescence via the GSK3β/β-catenin-WIP1 pathway

Developmental disorders characterized by small body size have been linked to CDK5RAP2 loss-of-function mutations, but the mechanisms underlying which remain obscure. Here, we demonstrate that knocking down CDK5RAP2 in human fibroblasts triggers premature cell senescence that is recapitulated in Cdk5...

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Detalles Bibliográficos
Autores principales: Wang, Xidi, Sipila, Patrick, Si, Zizhen, Rosales, Jesusa L., Gao, Xu, Lee, Ki-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688469/
https://www.ncbi.nlm.nih.gov/pubmed/34930892
http://dx.doi.org/10.1038/s41419-021-04457-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688469/
https://www.ncbi.nlm.nih.gov/pubmed/34930892
http://dx.doi.org/10.1038/s41419-021-04457-2

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