Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Parkinson’s disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their...

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Detalles Bibliográficos
Autores principales: Storm, Catherine S., Kia, Demis A., Almramhi, Mona M., Bandres-Ciga, Sara, Finan, Chris, Hingorani, Aroon D., Wood, Nicholas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688480/
https://www.ncbi.nlm.nih.gov/pubmed/34930919
http://dx.doi.org/10.1038/s41467-021-26280-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688480/
https://www.ncbi.nlm.nih.gov/pubmed/34930919
http://dx.doi.org/10.1038/s41467-021-26280-1

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