Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s disease

The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species implicated in the pathogenesis of PD. We aimed to evaluate by skin biopsy the diagnostic and prognostic capacity of αSyn-PLA and small nerve fiber reductio...

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Detalles Bibliográficos
Autores principales: Vacchi, Elena, Senese, Camilla, Chiaro, Giacomo, Disanto, Giulio, Pinton, Sandra, Morandi, Sara, Bertaina, Ilaria, Bianco, Giovanni, Staedler, Claudio, Galati, Salvatore, Gobbi, Claudio, Kaelin-Lang, Alain, Melli, Giorgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688481/
https://www.ncbi.nlm.nih.gov/pubmed/34930911
http://dx.doi.org/10.1038/s41531-021-00262-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688481/
https://www.ncbi.nlm.nih.gov/pubmed/34930911
http://dx.doi.org/10.1038/s41531-021-00262-y

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