Cargando…

Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1

INTRODUCTION: With the aim of repositioning commercially available drugs for the inhibition of the anti-apoptotic myeloid cell leukemia protein, Mcl-1, implied in various cancers, five molecules, highlighted from a published theoretical screening, were selected to experimentally validate their affin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bourafai-Aziez, Asma, Benabderrahmane, Mohammed, Paysant, Hippolyte, Weiswald, Louis-Bastien, Poulain, Laurent, Carlier, Ludovic, Ravault, Delphine, Jouanne, Marie, Coadou, Gaël, Oulyadi, Hassan, Voisin-Chiret, Anne-Sophie, Sopková-de Oliveira Santos, Jana, Sebban, Muriel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688747/ https://www.ncbi.nlm.nih.gov/pubmed/34949914 http://dx.doi.org/10.2147/DDDT.S323077

Ejemplares similares

Nutrient Requirements during Pregnancy and Lactation
por: Jouanne, Marie, et al.
Publicado: (2021)

Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial
por: Wauquier, Fabien, et al.
Publicado: (2021)

Development, Validation, and Use of (1)H-NMR Spectroscopy for Evaluating the Quality of Acerola-Based Food Supplements and Quantifying Ascorbic Acid
por: Bourafai-Aziez, Asma, et al.
Publicado: (2022)

Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain
por: Farag, Marc, et al.
Publicado: (2023)

Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐x(L) Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches
por: Negi, Arvind, et al.
Publicado: (2022)

Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk
por: Ahmad, Mohammad, et al.
Publicado: (2023)

Hypersensitivity reaction with deferasirox
por: Sharma, Atul, et al.
Publicado: (2015)

Structural transitions in TCTP tumor protein upon binding to the anti-apoptotic protein family member Mcl-1
por: Malard, Florian, et al.
Publicado: (2023)

Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
por: Negi, Arvind, et al.
Publicado: (2022)

Deferasirox: Duodenal perforation: case report
Publicado: (2021)

Fluorocyclopropane-Containing Proline Analogue: Synthesis and Conformation of an Item in the Peptide Chemistʼs Toolbox
por: Pons, Amandine, et al.
Publicado: (2022)

Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload
por: Wu, Dijiong, et al.
Publicado: (2018)

Characterization of Milkisin, a Novel Lipopeptide With Antimicrobial Properties Produced By Pseudomonas sp. UCMA 17988 Isolated From Bovine Raw Milk
por: Schlusselhuber, Margot, et al.
Publicado: (2018)

Corrigendum: Characterization of Milkisin, a Novel Lipopeptide With Antimicrobial Properties Produced By Pseudomonas sp. UCMA 17988 Isolated From Bovine Raw Milk
por: Schlusselhuber, Margot, et al.
Publicado: (2020)

Update on the use of deferasirox in the management of iron overload
por: Taher, Ali, et al.
Publicado: (2009)

Pharmacogenetic Study of Deferasirox, an Iron Chelating Agent
por: Lee, Ji Won, et al.
Publicado: (2013)

Deferasirox: Over a Decade of Experience in Thalassemia
por: Moukalled, Nour M., et al.
Publicado: (2018)

Deferasirox – a rarer cause of Fanconi syndrome
por: Khan, Iman, et al.
Publicado: (2019)

Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids
por: Gascon, Jose Miguel, et al.
Publicado: (2019)

Evaluation of Pharmacokinetics and Pharmacodynamics of Deferasirox in Pediatric Patients
por: Galeotti, Laura, et al.
Publicado: (2021)

Deferasirox Reduces Oxidative Stress in Patients With Transfusion Dependency
por: Saigo, Katsuyasu, et al.
Publicado: (2013)

Deferasirox: appraisal of safety and efficacy in long-term therapy
por: Chaudhary, Preeti, et al.
Publicado: (2013)

Modulation of the Immune Response by Deferasirox in Myelodysplastic Syndrome Patients
por: Votavova, Hana, et al.
Publicado: (2021)

Pharmacological and clinical evaluation of deferasirox formulations for treatment tailoring
por: Piolatto, Andrea, et al.
Publicado: (2021)

Effects of Deferasirox in Alzheimer’s Disease and Tauopathy Animal Models
por: Kwan, Ping, et al.
Publicado: (2022)

Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery
por: Faizi, Hafsa Shahid, et al.
Publicado: (2022)

Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma
por: Thorel, Lucie, et al.
Publicado: (2023)

Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib
por: Florent, Romane, et al.
Publicado: (2020)

Spherical Cancer Models in Tumor Biology()
por: Weiswald, Louis-Bastien, et al.
Publicado: (2015)

Deferasirox in Indian children with thalassemia major: 3 years experience
por: Dhamija, Mayank, et al.
Publicado: (2013)

The potential of deferasirox as a novel therapeutic modality in gastric cancer
por: Choi, Jung Hye, et al.
Publicado: (2016)

Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma
por: Saeki, Issei, et al.
Publicado: (2016)

Perforated duodenal ulcer: A rare complication of deferasirox in children
por: Yadav, Sunil Kumar, et al.
Publicado: (2013)

Deferasirox-induced urticarial vasculitis in a patient with myelodysplastic syndrome
por: Polat, Asude Kara, et al.
Publicado: (2017)

Protein Carbonylation in Patients with Myelodysplastic Syndrome: An Opportunity for Deferasirox Therapy
por: Rodríguez-García, Alba, et al.
Publicado: (2019)

From Biology to Clinical Practice: Iron Chelation Therapy With Deferasirox
por: Palumbo, Giuseppe A., et al.
Publicado: (2021)

Kidney Tubular Damage Secondary to Deferasirox: Systematic Literature Review
por: Scoglio, Martin, et al.
Publicado: (2021)

Concurrent use of hydroxyurea and deferasirox in Californians with sickle cell disease
por: Wong, Trisha E., et al.
Publicado: (2021)

Efficient and Simple Synthesis of 6-Aryl-1,4-dimethyl-9H-carbazoles
por: Caruso, Anna, et al.
Publicado: (2008)

Effects of oral iron chelator deferasirox on human malignant lymphoma cells
por: Choi, Jong Gwon, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9cl9ospsvccfnjm6tv1jabr5ic