Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma

BACKGROUND: Both anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cells (HBECs), targets for SARS-CoV-2 infectivity. O...

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Detalles Bibliográficos
Autores principales: Nieto-Fontarigo, Juan José, Tillgren, Sofia, Cerps, Samuel, Sverrild, Asger, Hvidtfeldt, Morten, Ramu, Sangeetha, Menzel, Mandy, Sander, Adam Frederik, Porsbjerg, Celeste, Uller, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688760/
https://www.ncbi.nlm.nih.gov/pubmed/34950134
http://dx.doi.org/10.3389/fimmu.2021.743890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688760/
https://www.ncbi.nlm.nih.gov/pubmed/34950134
http://dx.doi.org/10.3389/fimmu.2021.743890

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