Beneficial Effect of Phenytoin and Carbamazepine on GFAP Gene Expression and Mutant GFAP Folding in a Cellular Model of Alexander’s Disease

Alexander’s disease (AxD) is a rare, usually relentlessly progressive disorder of astroglial cells in the central nervous system related to mutations in the gene encoding the type III intermediate filament protein, glial fibrillary acidic protein (GFAP). The pathophysiology of AxD is only partially...

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Detalles Bibliográficos
Autores principales: Bachetti, Tiziana, Zanni, Eleonora Di, Adamo, Annalisa, Rosamilia, Francesca, Sechi, M. Margherita, Solla, Paolo, Bozzo, Matteo, Ceccherini, Isabella, Sechi, GianPietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688807/
https://www.ncbi.nlm.nih.gov/pubmed/34950024
http://dx.doi.org/10.3389/fphar.2021.723218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688807/
https://www.ncbi.nlm.nih.gov/pubmed/34950024
http://dx.doi.org/10.3389/fphar.2021.723218

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