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Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in the Drosophila Mitochondrial Replicative DNA Helicase

Recent evidence suggests that iron-sulfur clusters (ISCs) in DNA replicative proteins sense DNA-mediated charge transfer to modulate nuclear DNA replication. In the mitochondrial DNA replisome, only the replicative DNA helicase (mtDNA helicase) from Drosophila melanogaster (Dm) has been shown to con...

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Detalles Bibliográficos
Autores principales: So, Minyoung, Stiban, Johnny, Ciesielski, Grzegorz L., Hovde, Stacy L., Kaguni, Laurie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688847/
https://www.ncbi.nlm.nih.gov/pubmed/34950192
http://dx.doi.org/10.3389/fgene.2021.790521