Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics

In the current study, we report computational scores for advancing genomic interpretation of disease-associated genomic variation in members of the RAS family of genes. For this purpose, we applied 31 sequence- and 3D structure-based computational scores, chosen by their breadth of biophysical prope...

Descripción completa

Detalles Bibliográficos
Autores principales: Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Leverence, Elise, Urrutia, Raul, Zimmermann, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688876/
https://www.ncbi.nlm.nih.gov/pubmed/34976316
http://dx.doi.org/10.1016/j.csbj.2021.12.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688876/
https://www.ncbi.nlm.nih.gov/pubmed/34976316
http://dx.doi.org/10.1016/j.csbj.2021.12.007

Ejemplares similares