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Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics
In the current study, we report computational scores for advancing genomic interpretation of disease-associated genomic variation in members of the RAS family of genes. For this purpose, we applied 31 sequence- and 3D structure-based computational scores, chosen by their breadth of biophysical prope...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688876/ https://www.ncbi.nlm.nih.gov/pubmed/34976316 http://dx.doi.org/10.1016/j.csbj.2021.12.007 |